کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9416623 | 1292977 | 2005 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Single neuron activity changes to interleukin-1β in the orbitofrontal cortex of the rat
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Single neuron activity changes to interleukin-1β in the orbitofrontal cortex of the rat Single neuron activity changes to interleukin-1β in the orbitofrontal cortex of the rat](/preview/png/9416623.png)
چکیده انگلیسی
The orbitofrontal cortex (OBF) is known to play important roles in various regulatory processes. Our preliminary behavioral studies showed homeostatic alterations after orbitofrontal cortical microinjection of interleukin-1β (IL-1β) in the rat. To elucidate whether the above alterations were due to direct neuronal action of the cytokine, extracellular single neuron activity was recorded in the OBF of anesthetized rats by means of tungsten fiber multibarreled glass microelectrodes during microelectrophoretic administration of IL-1β. More than half (56%) of all cells tested changed in firing rate in response to IL-1β. Approximately 90% of these cytokine-modulated neurons were also sensitive to microelectrophoretically applied d-glucose, that is, proved to be the elements of the central glucose-monitoring neural network. The present findings demonstrate that IL-1β can exert direct modulatory role on neurons in the OBF.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Brain Research - Volume 1038, Issue 2, 21 March 2005, Pages 243-246
Journal: Brain Research - Volume 1038, Issue 2, 21 March 2005, Pages 243-246
نویسندگان
Balázs Lukáts, Róbert Egyed, Zoltán Karádi,