کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9416776 | 1614338 | 2005 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Strengthening of non-NMDA receptor-dependent horizontal pathways between primary and lateral secondary visual cortices after NMDA receptor-dependent oscillatory neural activities
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کلمات کلیدی
NMDA receptor - NMDA گیرندهHorizontal propagation - انتشار افقیExcitable membranes and synaptic transmission - غشاء جذاب و انتقال سیناپسیprimary visual cortex - قشر بصری اولیهsecondary visual cortex - قشر متوسط ثانویهPostsynaptic mechanisms - مکانیزم های پستoscillation - نوسانCaffeine - کافئینNon-NMDA receptor - گیرنده غیر NMDA
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Strengthening of non-NMDA receptor-dependent horizontal pathways between primary and lateral secondary visual cortices after NMDA receptor-dependent oscillatory neural activities Strengthening of non-NMDA receptor-dependent horizontal pathways between primary and lateral secondary visual cortices after NMDA receptor-dependent oscillatory neural activities](/preview/png/9416776.png)
چکیده انگلیسی
Emergence of oscillatory signal flows between the primary visual cortex (Oc1) and medial secondary visual cortex (Oc2M) was previously dynamically demonstrated in rat brain slices by us. Applying caffeine, a neural modulator, to the slices and using optical recording methods revealed this facilitation along horizontal intrinsic pathways in which initial forward propagation from Oc1 to Oc2M was dependent on both N-methyl-d-aspartate receptors (NMDARs) and non-NMDARs. Conversely, oscillatory backward propagation from Oc2M to Oc1 was entirely dependent on NMDARs. The present study examined: (1) whether the signal behavior between Oc1 and lateral secondary visual cortex (Oc2L) is based on the same mechanism with that between Oc1 and Oc2M; and (2) how non-NMDAR and NMDAR activities underlie opening of horizontal corticocortical pathways between Oc1 and Oc2. Under NMDAR blockade, signals elicited in the Oc1 either could not or only weakly penetrated the Oc2L, even in caffeine-containing medium. In contrast, once forward propagation from Oc1 to Oc2L and oscillatory backward propagation from Oc2L to Oc1 was established in caffeine-containing medium, signals elicited in Oc1 could strongly penetrate the Oc2 even during blockade of NMDA activities, when forward penetrating components were dependent on non-NMDARs. These findings suggest that: (1) signal behavior and its mechanism between Oc1and Oc2L are the same with those between Oc1 and Oc2M; and (2) NMDAR activation results in non-NMDAR activity, resulting in opening and strengthening of intrinsic signal pathways between Oc1 and Oc2. NMDAR-dependent forward and backward propagation might be involved in cortical reorganization of the visual cortex.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Brain Research - Volume 1036, Issues 1â2, 2 March 2005, Pages 60-69
Journal: Brain Research - Volume 1036, Issues 1â2, 2 March 2005, Pages 60-69
نویسندگان
Hiroshi Yoshimura, Tokio Sugai, Natsuki Segami, Norihiko Onoda,