کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
9422669 1613743 2018 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Nrf2 deletion results in imparied performance in memory tasks and hyperactivity in mature and aged mice
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
Nrf2 deletion results in imparied performance in memory tasks and hyperactivity in mature and aged mice
چکیده انگلیسی
Oxidative stress has been implicated in both the functional and cognitive decline associated with neuropsychiatric diseases and aging. A master regulator of the body's defense mechanism against oxidative stress is nuclear factor erythroid 2-related factor (NRF2). Here we investigated the effects of NRF2 deletion on motor and cognitive performance in “Aged” mice (17-25 months old) as compared to “Mature” mice (3-15 months old). We observed that the Aged Nrf2−/− mice were hyperactive and exhibited impaired acquisition of an active avoidance response. Furthermore, the Mature mice also displayed a hyperactive phenotype and had impaired working memory in the probe trial of the water radial arm maze. Overall, it appears that NRF2 may be implicated in memory and activity functions and its deletion exacerbates deficits associated with aging. These observations provide a model for assessing the role of oxidative stress in age-related disorders.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Brain Research - Volume 1701, 15 December 2018, Pages 103-111
نویسندگان
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