کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
9423047 1294768 2005 12 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Cross talk between growth factors and viral and cellular factors alters neuronal signaling pathways: Implication for HIV-associated dementia
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
Cross talk between growth factors and viral and cellular factors alters neuronal signaling pathways: Implication for HIV-associated dementia
چکیده انگلیسی
HIV-associated dementia (HAD) is a serious neurological disorder affecting about 7% of people with AIDS. In the brain, HIV-1 infects a restricted number of cell types, being primarily present in macrophages and microglial cells, less abundant in astrocytes, and rarely seen in oligodendrocytes and neurons. Lack of a productive HIV-1 infection of neuronal cells suggests the presence of an indirect pathway by which the virus may determine the brain pathology and neuronal dysfunction seen in AIDS patients. Among the participants in this event, viral proteins including gp120 and Tat, along with host factors including cytokines, chemokines, and several signaling pathways have received considerable attention. In this article, we discuss the most recent concepts pertaining to the mechanisms of HIV-1-induced neuronal dysfunction by highlighting the interplay between signal transduction pathways activated by viral and host factors and their consequences in neuronal cell function.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Brain Research Reviews - Volume 50, Issue 1, 1 December 2005, Pages 114-125
نویسندگان
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