کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9424208 | 1614662 | 2005 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
A model of incisional pain: the effects of dermal tail incision on pain behaviours of Sprague Dawley rats
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
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چکیده انگلیسی
Hyperalgesia, a component of post-operative pain, is an enhanced responsiveness to painful challenges after the tissue damage caused by an incision. It is important to understand the mechanisms involved in the development of incisional pain, in order to treat the condition appropriately. The aim of this study was to develop a model of post-operative pain using the rat's tail. Under halothane-induced anaesthesia, female Sprague Dawley rats underwent 10 mm longitudinal incisions through skin and fascia (n = 10) or 20 mm incisions through skin, fascia and muscle (n = 10) of the mid-portion of the tail. Control rats were only anaesthetised (n = 14). Withdrawal latencies to noxious mechanical and thermal challenges were recorded daily. A bar algometer was placed onto and 15 mm proximal to the incision with a force of 4 N and the tail was immersed in 49 °C water. Daily withdrawal latencies were compared to pre-incision values using one way analysis of variance (ANOVA) with Dunnett's post-hoc test. Primary mechanical hyperalgesia lasted for 6 days after the 10 mm incisions (P < 0.0001) and for 7 days after the 20 mm incisions (P < 0.0001). Secondary mechanical hyperalgesia persisted for 1 day after the 10 mm incisions (P = 0.0013) and for 2 days after the 20 mm incisions (P = 0.0028). Thermal hyperalgesia was not elicited. This model is suitable to examine the mechanisms involved in post-operative pain.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Neuroscience Methods - Volume 145, Issues 1â2, 30 June 2005, Pages 167-173
Journal: Journal of Neuroscience Methods - Volume 145, Issues 1â2, 30 June 2005, Pages 167-173
نویسندگان
Juliane Weber, Lisa Loram, Bridget Mitchell, Andreas Themistocleous,