کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9425476 | 1295874 | 2005 | 13 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
AMPA receptor modulators have different impact on hippocampal pyramidal cells and interneurons
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کلمات کلیدی
IPSPCX546CX516stratum oriensNASPMaCSF1-Naphthyl acetyl spermine - 1- نپتیل استیل اسپرمینEPSC - EPSCoREPSP - epspistratum radiatum - stratat radiatumlong-term potentiation - تقویت درازمدتLTP - تقویت طولانی مدت یا LTP excitatory postsynaptic current - جریان پستیینپتیک تحریک کنندهcyclothiazide - سیکلوتیازیدartificial cerebrospinal fluid - مایع مغزی نخاعی مصنوعیexcitatory postsynaptic potential - پتانسیل پست سیناپتی هیجان انگیزinhibitory postsynaptic potential - پتانسیل پستانیپتیک مهارکننده
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
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چکیده انگلیسی
Positive modulators of AMPA receptors enhance synaptic plasticity and memory encoding. Facilitation of AMPA receptor currents not only results in enhanced activation of excitatory neurons but also increases the activity of inhibitory interneurons by up-modulating their excitatory input. However, little is known about the effects of these modulators on cells other than pyramidal neurons and about their impact on local microcircuits. This study examined the effects of members from three subfamilies of modulators (mainly CX516, CX546 and cyclothiazide) on excitatory synaptic responses in four classes of hippocampal CA1 neurons and on excitatory and disynaptically induced inhibitory field potentials in hippocampal slices. Effects on excitatory postsynaptic currents (EPSCs) were examined in pyramidal cells, in two types of inhibitory interneurons located in stratum radiatum and oriens, and in stratum radiatum giant cells, a novel type of excitatory neuron. With CX516, increases in EPSC amplitude in pyramidal cells were two to three times larger than in interneurons and six times larger than in radiatum giant cells. The effects of CX546 on response duration similarly were largest in pyramidal cells. However, this drug also strongly differentiated between stratum oriens and radiatum interneurons with increases being four times larger in the latter. In contrast, cyclothiazide had similar effects on response duration in all cell types. In field recordings, CX516 was several times more potent in enhancing excitatory postsynaptic potentials (EPSPs) than feedback or feedforward circuits, as expected from its larger influence on pyramidal cells. In contrast, BDP-20, a CX546 analog, was more potent in enhancing feedforward inhibition than either EPSPs or feedback inhibition. This preference for feedforward over feedback circuits is probably related to its higher potency in stratum radiatum versus oriens interneurons. Taken together, AMPA receptor modulators differ substantially in their potency and/or efficacy across major classes of neurons which is likely to have consequences with regard to their impact on circuits and behavior.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience - Volume 135, Issue 2, 2005, Pages 555-567
Journal: Neuroscience - Volume 135, Issue 2, 2005, Pages 555-567
نویسندگان
Y.-F. Xia, A.C. Arai,