کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
9434920 1298212 2005 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
No association of FOXP2 and PTPRZ1 on 7q31 with autism from the Japanese population
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
No association of FOXP2 and PTPRZ1 on 7q31 with autism from the Japanese population
چکیده انگلیسی
Autism is a child-onset pervasive developmental disorder, with a significant role of genetic factors in its development. Genome-wide linkage studies have suggested a 7q region as a susceptibility locus for autism. We investigated several single nucleotide polymorphisms (SNPs) of Forkhead Box P2 (FOXP2) and Protein-Tyrosine Phosphatase, Receptor-type, Zeta-1 (PTPRZ1) at the 7q region in Japanese patients with autism and healthy controls. No significant difference was observed, after correction for the multiple testing, in allele, genotype or haplotype frequencies of the SNPs of FOXP2 or PTPRZ1 between patients and controls. No evidence was thus obtained for a major role of FOXP2 or PTPRZ1 in the development of autism.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience Research - Volume 53, Issue 1, September 2005, Pages 91-94
نویسندگان
, , , , , , , , , , , , ,