کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
949448 926751 2014 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Increased depression risk among patients with chronic osteomyelitis
ترجمه فارسی عنوان
افزایش خطر افسردگی در بیماران مبتلا به استئومیلیت مزمن
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی روانپزشکی بیولوژیکی
چکیده انگلیسی


• Chronic osteomyelitis (COM) increased the risk of depression development.
• Comorbidities were more frequently seen in the COM cohort.
• The younger population carried even greater risk for depression.

ObjectiveInflammatory processes, which provoke alternations of neurotransmitter metabolism, neuroendocrine function, and neuroplasticity in the brain, might promote depression. In depression patients who do not exhibit risk factors, including hypertension, diabetes, coronary heart disease, stroke, Parkinson's disease and dementia, particularly in young people, inflammation is a likely risk factor for depression. We explored whether chronic osteomyelitis (COM), a chronic inflammatory disease, increases depression risk.MethodsA Taiwanese national insurance claims data set of more than 22 million enrollees was used to select 15,529 COM patients without depression history and 62,116 randomly selected age- and gender-matched controls without depression and COM history to trace depression development for an 12-year follow-up period from January 1, 1999 to December 31, 2010. The depression risk was analyzed using the Cox proportional hazards regression model.ResultsThe above-mentioned risk factors for depression were more frequent in the COM cohort, who exhibited significantly higher depression risk than the control group did. Comparing only those without comorbidities, the COM group exhibited higher depression risk than the control group did (hazard ratio [HR] = 3.04, 95% confidence interval [CI]: 2.55–3.62). The younger population carried even greater risk (age < 45: HR = 6.08, 95% CI: 1.71–7.85; age > 65: HR = 1.75, 95% CI: 1.39–2.19).ConclusionsThis is the first study connecting COM to increased risk of developing depression. The outcomes suggest that COM is a substantial depression predictor and call for a closer focus on these patients for more rigorous depression prevention, particularly in young people.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Psychosomatic Research - Volume 77, Issue 6, December 2014, Pages 535–540
نویسندگان
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