کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
949491 926755 2013 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Maternal prenatal symptoms of depression and down regulation of placental monoamine oxidase A expression
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی روانپزشکی بیولوژیکی
پیش نمایش صفحه اول مقاله
Maternal prenatal symptoms of depression and down regulation of placental monoamine oxidase A expression
چکیده انگلیسی

ObjectiveMaternal prenatal symptoms of depression and anxiety have been associated with altered neurodevelopmental outcomes in the child. These effects may be mediated in part by altered placental function, with increased fetal 5-hydroxytryptamine (5-HT) exposure being one possible mechanism. The current study aimed to determine whether maternal symptoms of depression or anxiety were associated with decreased placental expression of monoamine oxidase A (MAO A), the enzyme which metabolises 5-HT into 5-hydroxyindoleacetic acid. The localisation of MAO A in the placenta was also investigated.MethodsPregnant women were recruited one day prior to elective caesarean and assessed using psychometric tests for symptoms of depression (Edinburgh Depression Scale) and anxiety (Spielberger State/Trait Index). Villous trophoblast tissue was extracted from each placenta and used for subsequent gene expression analysis (N = 62). Localisation was studied using immunohistochemistry, with a specific polyclonal antibody.ResultsIncreasing symptoms of maternal depression were associated with a reduction in placental MAO A expression (r = − 0.339, p = 0.007, N = 62). There was a trend for a similar correlation with symptoms of maternal trait anxiety, but not with state anxiety. MAO A was localised to the syncytiotrophoblast, the tissue between maternal and fetal blood.ConclusionsThese findings support the hypothesis that maternal mood is associated with altered placental function. A reduction in placental MAO A expression is consistent with a subsequent increase in fetal exposure to 5-HT.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Psychosomatic Research - Volume 75, Issue 4, October 2013, Pages 341–345
نویسندگان
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