کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
949554 926765 2012 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Methodological aspects of clinical trials in tinnitus: A proposal for an international standard
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی روانپزشکی بیولوژیکی
پیش نمایش صفحه اول مقاله
Methodological aspects of clinical trials in tinnitus: A proposal for an international standard
چکیده انگلیسی

Chronic tinnitus is a common condition with a high burden of disease. While many different treatments are used in clinical practice, the evidence for the efficacy of these treatments is low and the variance of treatment response between individuals is high. This is most likely due to the great heterogeneity of tinnitus with respect to clinical features as well as underlying pathophysiological mechanisms. There is a clear need to find effective treatment options in tinnitus, however, clinical trials differ substantially with respect to methodological quality and design. Consequently, the conclusions that can be derived from these studies are limited and jeopardize comparison between studies. Here, we discuss our view of the most important aspects of trial design in clinical studies in tinnitus and make suggestions for an international methodological standard in tinnitus trials. We hope that the proposed methodological standard will stimulate scientific discussion and will help to improve the quality of trials in tinnitus.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Psychosomatic Research - Volume 73, Issue 2, August 2012, Pages 112–121
نویسندگان
, , , , , , , , , , , , , , ,