Accurate dynamical models of interneuronal GABAergic channel physiologies

Recent experimental results have revealed a large diversity of anatomic, synaptic and membrane physiology within the GABAergic system. By incorporating combinations of parametrically varied M-type, A-type, and calcium-dependent potassium (AHP) channels, we were able to replicate in vitro responses to 1-second current steps ranging from 50 to 350 pA. Our results show the need for subthreshold activating channels to capture the physiological properties of GABAergic cells. Presently underway is a collaboration among the authors to corroborate the proposed channel models using genetic profiles obtained from physiologically characterized interneurons.