کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9653527 | 679194 | 2005 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
A theoretical computer model of cellular modification associated with olfactory learning in the rat piriform cortex
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موضوعات مرتبط
مهندسی و علوم پایه
مهندسی کامپیوتر
هوش مصنوعی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Our goal in the present study is to analyze and explain through computational techniques the effect of increased EPSP depression after learning. We apply three different models to simulate the exact reduction in the AHP amplitude: (1) ''Conductance change:'' Controlled by decreasing gkCa by 40 %. (2) ''Moving:'' Shifting the location of the dendritic segment that exhibits active conductances, including AHP conductance, distally from the soma, while decreasing gkCa by only 15%. (3) ''Shrinkage:'' Decreasing the length of the AHP dendritic segment, while increasing gkCa by 9%. Moving the synaptic input distally from the soma enhances EPSP depression by the AHP conductance. Hence, the learning process could be simulated by a “jump” from the control curve to any other curve, representing decreased AHP amplitude. At the same time, the enhanced EPSP depression requires an additional shift of the EPSP input to more distal locations.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neurocomputing - Volumes 65â66, June 2005, Pages 549-555
Journal: Neurocomputing - Volumes 65â66, June 2005, Pages 549-555
نویسندگان
G. Gradwohl, Y. Grossman,