کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9697 | 643 | 2010 | 6 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: A circular cross-section PDMS microfluidics system for replication of cardiovascular flow conditions A circular cross-section PDMS microfluidics system for replication of cardiovascular flow conditions](/preview/png/9697.png)
Since the inception of soft lithography, microfluidic devices for cardiovascular research have been fabricated easily and cost-effectively using the soft lithography method. The drawback of this method was the fabrication of microchannels with rectangular cross-sections, which did not replicate the circular cross-sections of blood vessels. This article presents a novel, straightforward approach for the fabrication of microchannels with circular cross-sections in poly(dimethylsiloxane) (PDMS), using soft lithography. The method exploits the polymerization of the liquid silicone oligomer around a gas stream when both of them are coaxially introduced in the microchannel with a rectangular cross-section. We demonstrate (i) the ability to control the diameter of circular cross-sections of microchannels from ca. 40–100 μm; (ii) the fabrication of microchannels with constrictions, and (iii) the capability to grow endothelial cells on the inner surface of the microchannels.
Journal: Biomaterials - Volume 31, Issue 13, May 2010, Pages 3459–3464