کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
9721 643 2010 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Water-soluble superparamagnetic manganese ferrite nanoparticles for magnetic resonance imaging
موضوعات مرتبط
مهندسی و علوم پایه مهندسی شیمی بیو مهندسی (مهندسی زیستی)
پیش نمایش صفحه اول مقاله
Water-soluble superparamagnetic manganese ferrite nanoparticles for magnetic resonance imaging
چکیده انگلیسی

We report here a thermal decomposition approach to the synthesis of water-soluble superparamagnetic manganese ferrite (MnFe2O4) nanoparticles (NPs) for magnetic resonance (MR) imaging applications. In this approach, tetraethylene glycol was utilized as a coordination and stabilization agent, rendering the NPs water-soluble and stable. The formed NPs had a diameter of 7 nm with a narrow size distribution, and were superparamagnetic with a saturated magnetization (Ms) of 39 emu/g. In vitro cytotoxicity test revealed that the MnFe2O4 NPs were biocompatible at a particle concentration below 200 μg/mL. The transverse relaxivity of MnFe2O4 NPs in water and cells after incubation were determined to be 189.3 mm−1 s−1 and 36.8 mm−1 s−1 based on iron concentration, respectively. In vivo MR imaging studies in conjunction with inductively coupled plasma-atomic emission spectroscopy showed that the MnFe2O4 NPs were preferentially accumulated in liver after intravenous injection for 4 h. This suggests that the developed MnFe2O4 NPs can serve as a sensitive MR imaging contrast agent for liver imaging. By appropriately modifying or functionalizing the surface of the NPs, these particles may be used for MR detection of other diseases.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biomaterials - Volume 31, Issue 13, May 2010, Pages 3667–3673
نویسندگان
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