Determination of alkali metals in control and AD brain samples by different techniques

Despite the merits of the technique, its drawbacks are evident. Therefore, applicability of rapid spectrochemical methods as alternatives has been investigated. ICP-AES has been used for analysis of Li, Na and K. No interferences were observed, but ultrasonic nebulisation was needed for Li quantification. Rb and Cs were measured by ICP-MS with In as internal standard. Agreement between different techniques is found to be good for Na, K and Rb, while Cs values show somewhat higher differences.