کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9769151 | 1501241 | 2005 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Synthesis of 2,6-diphenylpyrazine derivatives and their DNA binding and cytotoxic properties
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Synthesis of 2,6-diphenylpyrazine derivatives and their DNA binding and cytotoxic properties Synthesis of 2,6-diphenylpyrazine derivatives and their DNA binding and cytotoxic properties](/preview/png/9769151.png)
چکیده انگلیسی
A series of 2,6-diphenylpyrazine derivatives was synthesized from 2,6-dichloropyrazine and 4-methoxyphenylboronic acid using palladium(0) as catalyst in a Suzuki methodology. After deprotection of the hydroxyl, alkylation reactions with different halides afforded compounds 5-8 bearing hydrophilic chains. DNA binding and cytotoxic properties were investigated. Compound 11 bearing imidazoline terminal groups was found to be a potent AT-specific DNA minor groove binder but there was no relationship between DNA interaction and cytotoxicity. However, in all cases the incorporation of the pyrazine ring was found to promote the cytotoxicity of the molecules compared to the corresponding pyridine analogues, previously synthesized.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Medicinal Chemistry - Volume 40, Issue 12, December 2005, Pages 1206-1213
Journal: European Journal of Medicinal Chemistry - Volume 40, Issue 12, December 2005, Pages 1206-1213
نویسندگان
Nathalie Dias, Ulrich Jacquemard, Brigitte Baldeyrou, Amélie Lansiaux, Jean-François Goossens, Christian Bailly, Sylvain Routier, Jean-Yves Mérour,