کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
9769226 1501244 2005 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Development of novel 4-aminopyridine derivatives as potential treatments for neurological injury and disease
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Development of novel 4-aminopyridine derivatives as potential treatments for neurological injury and disease
چکیده انگلیسی
The amine position of the K+ channel blocker 4-aminopyridine was functionalized to form amide, carbamate and urea derivatives in an attempt to identify novel compounds which restore conduction in injured spinal cord. Eight derivatives were tested in vitro, using a double sucrose gap chamber, for the ability to restore conduction in isolated, injured guinea pig spinal cord. The methyl, ethyl and t-butyl carbamates of 4-aminopyridine induced an increase in the post injury compound action potential. The methyl and ethyl carbamates were further tested in an in vivo model of spinal cord injury. These results represent the first time that 4-aminopyridine has been derivatized without losing its ability to restore function in injured spinal cord tissue.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Medicinal Chemistry - Volume 40, Issue 9, September 2005, Pages 908-917
نویسندگان
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