کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9769268 | 1501247 | 2005 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Synthesis, physicochemical and in vitro pharmacological investigation of new platinum (II) complexes with some cycloalkanespiro-5â²-hydantoins
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Platinum (II) complexes with cyclobutanespiro-5â²-hydantoin and cycloheptanespiro-5â²-hydantoin were synthesized and evaluated by means of general physicochemical methods. The data from the elemental analysis, IR and NMR spectra suggested the formation of cis-[Pt(C6H8N2O2)2(NH3)2](NO3)2·4H2O (PtCBH), when cyclobutanespiro-5â²-hydantoin was used as a ligand and cis-[Pt(C9H14N2O2)(NH3)2](NO3)2·4H2O (PtCHTH), when cycloheptanespiro-5â²-hydantoin was used, respectively. The novel complexes exerted cytotoxic effects at micromolar concentrations against a panel of human tumor cell lines. They were found to trigger apoptosis in HL-60 and BV-173 cells as evidenced by DNA-laddering detection. The evaluation of the effects of PtCBH, PtCHTH and the antineoplastic drugs cisplatin and oxaliplatin against cultured murine kidney epithelial cells revealed that the hydantoin complexes were far less nephrotoxic in vitro.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Medicinal Chemistry - Volume 40, Issue 6, June 2005, Pages 590-596
Journal: European Journal of Medicinal Chemistry - Volume 40, Issue 6, June 2005, Pages 590-596
نویسندگان
Adriana Bakalova, Rossen Buyukliev, Georgi Momekov, Darvin Ivanov, Dimitar Todorov, Spiro Konstantinov, Margarita Karaivanova,