کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9801370 | 1515481 | 2005 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Self-assembly of cholesterol-hydrotropic dendrimer conjugates into micelle-like structure: Preparation and hydrotropic solubilization of paclitaxel
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
مهندسی مواد
دانش مواد (عمومی)
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Self-assembly of cholesterol-hydrotropic dendrimer conjugates into micelle-like structure: Preparation and hydrotropic solubilization of paclitaxel Self-assembly of cholesterol-hydrotropic dendrimer conjugates into micelle-like structure: Preparation and hydrotropic solubilization of paclitaxel](/preview/png/9801370.png)
چکیده انگلیسی
A hydrotropic dendrimer, made of polyglycerol dendrimer of generation 4 (PGD-G4), was conjugated with cholesterol. The self-assembled structure of the conjugate in water was characterized by 1H-NMR, dynamic light scattering (DLS) and atomic force microscopy (AFM). One cholesterol molecule was conjugated to PGD-G4, which was confirmed by MALDI-TOF mass spectroscopy. The DLS analysis showed that the conjugate formed self-assembly with a diameter of 49.9-59.9Â nm. The AFM image suggests that the self-assembly is a micelle-like sphere. The level of paclitaxel solubilization by the conjugate in water was similar to that of PGD-G4 itself, and this suggests that the PGD-G4 is located on the outer part of the self-assembly to function as a hydrotrope.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Science and Technology of Advanced Materials - Volume 6, Issue 5, July 2005, Pages 452-456
Journal: Science and Technology of Advanced Materials - Volume 6, Issue 5, July 2005, Pages 452-456
نویسندگان
Tooru Ooya, Kang Moo Huh, Masato Saitoh, Eiichi Tamiya, Kinam Park,