کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
9801373 1515481 2005 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Hydrophilized poly(lactide-co-glycolide) nanoparticles with core/shell structure for protein delivery
موضوعات مرتبط
مهندسی و علوم پایه مهندسی مواد دانش مواد (عمومی)
پیش نمایش صفحه اول مقاله
Hydrophilized poly(lactide-co-glycolide) nanoparticles with core/shell structure for protein delivery
چکیده انگلیسی
A novel preparation method for core/shell nanoparticles with hydrophilic polymeric shell was designed and characterized. The core is composed of poly(lactide-co-glycolide) and polymeric shell is composed of pluronics (poly (ethylene oxide)-poly (propylene oxide)-poly(ethylene oxide) triblock copolymer, F-127) and hyaluronic acid (HA). The role of core is to provide the nucleus for the stable formation of hydrophilic polymeric shell by physical adsorption and that of polymeric shell is to provide the hydrophilic network for protein loading. Lysozyme, which was used as a model drug and protonated in the physiological pH, was successfully loaded into polymeric shell up to 7 wt% via ionic interaction between HA and lysozyme and the sustained release pattern was observed, which was due to the stable immobilization of lysozyme in the polymeric shell.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Science and Technology of Advanced Materials - Volume 6, Issue 5, July 2005, Pages 468-474
نویسندگان
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