کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9818138 | 1518776 | 2005 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
In vitro and in vivo study of He+ ion irradiated collagen for development of small diameter stent graft material
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
مهندسی مواد
سطوح، پوششها و فیلمها
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چکیده انگلیسی
Recently, stent graft technology for endovascular treatment of aortic dissections has made tremendous advances. It is now possible to apply this minimally invasive technique to a wider range of pathology. The aim of this study was to develop anti-thrombogenic coronary stent and graft materials using ion-beam technology. Our previous study indicted that collagen surfaces irradiated with He+ ion at a fluence of 1Â ÃÂ 1014Â ions/cm2 have excellent blood compatibility. The ion-beam-irradiated collagen grafts demonstrated a high anti-thrombogenicity and graft patency. 150Â keV-He+-irradiated collagen with a fluence of 1Â ÃÂ 1014Â ions/cm2 has the properties of anti-thrombogenicity and cell attachment. In vitro plasma protein adsorption was evaluated to investigate the mechanisms of anti-thrombogenicity of these surfaces. From these results, anti-thrombogenicity of the He+-irradiated collagen was caused by the reduction of the plasma protein adsorption, such as fibrinogen or von Willebrand factor, by ion-beam irradiation. Japanese white rabbits weighing 3-4.5Â kg were used in this animal study. Collagen-coated graft material implanted with He+ ions at a fluence of 1Â ÃÂ 1014Â ions/cm2 exhibited excellent anti-thrombogenicity and demonstrated patency for one year.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms - Volume 232, Issues 1â4, May 2005, Pages 353-357
Journal: Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms - Volume 232, Issues 1â4, May 2005, Pages 353-357
نویسندگان
Y. Suzuki, M. Iwaki, N. Takahashi, T. Yotoriyama, K. Kurotobi, H. Ujiie, T. Hori,