کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
987773 935170 2012 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Cost-Effectiveness of Switching Patients with Type 2 Diabetes from Insulin Glargine to Insulin Detemir in Chinese Setting: A Health Economic Model Based on the PREDICTIVE Study
ترجمه فارسی عنوان
اثربخشی هزینه سوئیچینگ بیماران مبتلا به دیابت نوع 2 از گلارژین انسولین تا Detemir انسولین در تنظیم چینی: مدل اقتصادی بهداشتی بر اساس مطالعه پیشگویی
کلمات کلیدی
مراکز چینی؛ هزینه بهره وری؛ هزینه یابی؛ انسولین Detemir
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی پزشکی و دندانپزشکی (عمومی)
چکیده انگلیسی

ObjectivesTo evaluate the long-term cost-effectiveness of switching from insulin glargine (IGla) to insulin detemir (IDet) in patients with type 2 diabetes in the setting of Chinese secondary and tertiary hospitals.MethodsA published and validated computer simulation model of diabetes (the Center for Outcomes Research model) was used to make the long-term (30 years) projection of health economic outcomes. Patient demographic information and clinical end points were derived from a subgroup analysis of the Predictable Results and Experience in Diabetes through Intensification and Control to Target: an International Variability Evaluation (PREDICTIVE) study. Baseline risk factors and racial characteristic data were obtained from Chinese cohort studies. The diabetes management and complications costs were obtained from Chinese published data and adjusted to 2010 values by using the Chinese consumer price index. An annual discounting rate of 3% was used for both health and cost outcomes, and one-way sensitivities analysis was performed, which illustrated that the results were robust.ResultsConversion to IDet from IGla was projected to improve patient life expectancy by 0.06 year and 0.48 quality-adjusted life-years. Drug costs and management costs of diabetes mellitus were increased by US$368 (US$17,466 vs. US$17,097) and US$31 (US$5464 vs. US$5433), respectively. However, the costs of complications, including cerebrovascular disease, renal complications, ulcer/amputation/neuropathy, eye complications, and hypoglycemia events, were reduced by US$819 (US$21,294 vs. US$22,114), resulting in a total direct medical cost saving of US$420 when converting to IDet.ConclusionsConversion to IDet from an IGla regimen improved life expectancy and was a cost-saving treatment approach in a Chinese setting.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Value in Health - Volume 15, Issue 1, Supplement, January–February 2012, Pages S56–S59
نویسندگان
, , , ,