Malignant neuroblastic tumors in adolescents

Malignant neuroblastic tumors (MNT) commonly affect children in the early years of life and become rare afterwards. The clinical characteristics and outcome of these tumors occurring in adolescents are still unclear. In this review, the main clinical reports available in the literature are summarized together with some original data. In general, MNT occurring in adolescents, if compared to those occurring in children, are more frequently diagnosed in advanced stages, have uncommon sites of metastases, but have less frequently unfavorable biological markers. If treated with standard protocols as those used for children, their survival is poor; in particular, patients with localized disease seem to have a more aggressive course than children.