کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9905692 | 1547299 | 2005 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Outcome of patients with advanced gastro-intestinal stromal tumours crossing over to a daily imatinib dose of 800Â mg after progression on 400Â mg
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
تحقیقات سرطان
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Outcome of patients with advanced gastro-intestinal stromal tumours crossing over to a daily imatinib dose of 800Â mg after progression on 400Â mg Outcome of patients with advanced gastro-intestinal stromal tumours crossing over to a daily imatinib dose of 800Â mg after progression on 400Â mg](/preview/png/9905692.png)
چکیده انگلیسی
In the EORTC-ISG-AGITG trial 946 patients with advanced gastro-intestinal stromal tumours (GIST) were randomised to receive 400 or 800Â mg of imatinib daily. An increase in progression free survival (PFS) was demonstrated for patients randomised to the high-dose arm. Patients randomised to low-dose could cross-over to high-dose upon progression. We evaluated the feasibility, safety and efficacy of this policy. Of the 241 patients available for follow-up, 133 patients (55%) crossed over to high-dose imatinib according to the protocol. Of these patients, 92% had not had a prior dose reduction. The cumulative incidence of subsequent dose reductions after cross-over was 17% after six months with 51% discontinuing therapy without requiring a dose reduction. The extent of anaemia and fatigue increased significantly after cross-over, whilst neutropenia was less severe than during low-dose treatment. Objective responses after cross-over included three patients (2%) with a partial response and 36 (27%) with stable disease. The median PFS after cross-over was 81 days, although 18.1% of patients were still alive and progression free one year after cross-over. We conclude that a cross-over to high-dose imatinib is feasible and safe in GIST patients who progress on low-dose therapy.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Cancer - Volume 41, Issue 12, August 2005, Pages 1751-1757
Journal: European Journal of Cancer - Volume 41, Issue 12, August 2005, Pages 1751-1757
نویسندگان
John R. Zalcberg, Jaap Verweij, Paolo G. Casali, Axel Le Cesne, Peter Reichardt, Jean-Yves Blay, Marcus Schlemmer, Martine Van Glabbeke, Michelle Brown, Ian R. Judson, for the EORTC Soft Tissue and Bone Sarcoma Group,