کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9905846 | 1547306 | 2005 | 11 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Perinatal and reproductive factors: a report on haematological malignancies from the UKCCS
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
تحقیقات سرطان
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چکیده انگلیسی
Information on the conduct of this component of the study and results for 1485 children with haematological malignancies and 4864 controls are presented. The 'find' rate for obstetric records was high at 86% for cases, with 81% having information on both matched controls. Associations were seen for severe hyperemesis (Odds Ratio = 3.6, 95%Confidence Interval = 1.3-10.1, for all leukaemias), polyhydramnios (OR = 4.0, 95%CI = 1.5-10.3, for acute myeloid leukaemia (AML)), anaemia (haemoglobin <10 g, OR = 2.6, 95%CI = 1.7-4.1, for AML), and pre-eclampsia (OR = 1.7, 95%CI = 1.1-2.7, for non-Hodgkin's lymphoma). Babies who developed leukaemia were heavier at birth (>4000 g, OR = 1.2, 95%CI = 1.0-1.4), as were their older siblings (>4000 g, OR = 1.4, 95%1.0-1.9). Mothers' whose children developed common B-cell precursor acute lymphoblastic leukaemia (ALL) were more likely to have had a previous molar pregnancy (OR = 5.2, 95%CI = 1.9-14.7). Gender-specific analysis revealed that findings often differed markedly for boys and girls; and, in common with other reports, strong associations with Down's syndrome were seen for both ALL and AML.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Cancer - Volume 41, Issue 5, March 2005, Pages 749-759
Journal: European Journal of Cancer - Volume 41, Issue 5, March 2005, Pages 749-759
نویسندگان
E. Roman, J. Simpson, P. Ansell, T. Lightfoot, C. Mitchell, T.O.B. Eden, on behalf of the United Kingdom Childhood Cancer Study Investigators on behalf of the United Kingdom Childhood Cancer Study Investigators,