کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9905875 | 1547307 | 2005 | 11 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Thiopurine methyltransferase in acute lymphoblastic leukaemia: biochemical and molecular biological aspects
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
تحقیقات سرطان
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Thiopurine S-methyltransferase (TPMT) is a cytosolic enzyme, catalysing S-methylation of aromatic and heterocyclic sulphhydryl compounds. TPMT activities and genotypes have been determined in patients with acute lymphoblastic leukaemia (ALL) and in control children. Median red blood cell (RBC) TPMT activity in ALL patients at diagnosis was significantly lower than in controls (median 11.5 pmol/107 RBC*hr; range 1.7-30.7; n = 191 vs. 14.6 pmol/107 RBC*hr; range 1.6-50.7; n = 140). This reduction of TPMT activity in ALL patients was not due to differences in the frequency of mutations in the TPMT gene. In concordance with other authors, we found a higher TPMT activity during maintenance treatment with 6-mercaptopurine (6MP) than at diagnosis and in controls. However, we observed that TPMT activity was already significantly increased after the induction therapy, before the patients received 6MP (median 17.5; range 3.9-40.3 pmol/107 RBC*hr; n = 139). In vitro experiments indicate that the early increase of TPMT activity during treatment may be explained by the use of antifolates, e.g., methotrexate and trimethoprim.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Cancer - Volume 41, Issue 4, March 2005, Pages 613-623
Journal: European Journal of Cancer - Volume 41, Issue 4, March 2005, Pages 613-623
نویسندگان
Connie Brouwer, Ronney A. De Abreu, Jenneke J. Keizer-Garritsen, Lambert H.J. Lambooy, Kai Ament, Patricia G.J.H. ter Riet, Elisabeth R. van Wering, Frans J.M. Trijbels, Anjo J.P. Veerman, Peter M. Hoogerbrugge, Jos P.M. Bökkerink,