کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
9905893 1547308 2005 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Determining overdiagnosis by screening with DRE/TRUS or PSA (Florence pilot studies, 1991-1994)
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی تحقیقات سرطان
پیش نمایش صفحه اول مقاله
Determining overdiagnosis by screening with DRE/TRUS or PSA (Florence pilot studies, 1991-1994)
چکیده انگلیسی
The rate of overdiagnosis of prostate carcinoma was assessed by following 6890 participants in pilot screening studies from 1991 to 1994. Observed/expected incidence and mortality were determined using data from the Cancer and Mortality Registry. The cancer detection rate (1.75%) and observed/expected ratio (12.5:1) were high at the first screening, and substantially lower at the second screening (0.65% or 4.10:1). According to the registry follow-up, prostate cancer occurred in 225 subjects in the whole study cohort, while 178.2 were expected with 50 652 men/years at risk. The standardised incidence rate was 1.66 in the screened (95%CI = 1.4-2.0), 0.97 in the non-responders (95%CI = 0.8-1.2) and 1.23 in subjects excluded from invitation due to previous cancer or major illness (95%CI = 0.8-1.5). A 66% excess incidence rate was observed in the screened subjects over a 9-year period, confirming previous estimates of overdiagnosis.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Cancer - Volume 41, Issue 3, February 2005, Pages 411-415
نویسندگان
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