کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9905911 | 1547309 | 2005 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Intracellular signalling and cancer: complex pathways lead to multiple targets
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
تحقیقات سرطان
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چکیده انگلیسی
Normal cells proliferate, die and differentiate as and when they should for the proper functioning of any particular tissue type. These processes are governed by a complex series of intracellular pathways that have many internal checkpoints and safety nets. These ensuring a fine, but tight, balance on overall tissue growth and distribution. A series of key aberrations, resulting in the disruption of these intracellular pathways, can lead to the development of a malignancy. The nature of these alterations is often not only tumour-specific, but also different between individuals with the same tumour type. As a result, these pathways have to be carefully dissected and functionally assessed to identify valid targets with therapeutic potential in a wide range of tumour types.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Cancer - Volume 41, Issue 2, January 2005, Pages 206-215
Journal: European Journal of Cancer - Volume 41, Issue 2, January 2005, Pages 206-215
نویسندگان
Helen S. Bell, Kevin M. Ryan,