کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9905927 | 1547309 | 2005 | 11 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Molecular characterisation of two human cancer cell lines selected in vitro for their chemotherapeutic drug resistance to ET-743
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کلمات کلیدی
MicroarraysXPGET-743PKNcis-diamminedichloroplatinumDDHCDDPLysyl oxidase-like 1LOXL1GSTIC50MDRDMSO - DMSONER - DOWNLC–MS/MS - LC-MS / MSnucleotide excision repair - تعمیر مجدد نوکلئوتیدیDoxorubicin - دوکسوروبیسینdimethylsulphoxide - دی متیل سولفوکسیدMulti-drug resistance - مقاومت چند داروییNOTCH3 - نکات 3high-pressure liquid chromatography - کروماتوگرافی مایع با فشار بالاHPLC - کروماتوگرافی مایعی کاراglutathione S-transferase - گلوتاتیون S-ترانسفرازGlutamine synthase - گلوتامین سنتازGlul - گلولم
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
تحقیقات سرطان
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
ET-743 (YondelisTM, Trabectedin) isolated from the tunicate Ecteinascidia turbinata, is being tested in phase II clinical trials in Europe and the United States of America (USA). Studies with different solid tumours have shown antitumour activity in advanced, pre-treated sarcomas as well as in drug-resistant breast and ovarian cancer. The primary mechanism of action for ET-743 has not been fully elucidated and different models have been suggested to explain its molecular mechanism of action. ET-743 binds tightly to the minor groove of DNA and previous data have suggested that ET-743 acts by interfering with RNA transcription. To further investigate the mechanism of in vitro drug resistance, we evaluated the gene expression profile in ovarian and chondrosarcoma cell lines selected for resistance to ET-743. We found 70 genes whose expression was modulated in both drug-resistant cell lines when compared with their respective parental drug-sensitive cell lines. This pattern of gene expression seems to be selective for ET-743-resistant cells, since ovarian cancer cells resistant to paclitaxel did not share the same gene expression changes. Data presented in this study reveal different molecular pathways that could be involved in the cellular mechanism of ET-743 resistance.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Cancer - Volume 41, Issue 2, January 2005, Pages 323-333
Journal: European Journal of Cancer - Volume 41, Issue 2, January 2005, Pages 323-333
نویسندگان
S. Marchini, E. Marrazzo, R. Bonomi, G. Chiorino, M. Zaffaroni, L. Weissbach, F.J. Hornicek, M. Broggini, G.T. Faircloth, M. D'Incalci,