کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
990987 935573 2013 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
A Clinical Research Practice Datalink Analysis of Antidepressant Treatment Patterns and Health Care Costs in Generalized Anxiety Disorder
ترجمه فارسی عنوان
تجزیه و تحلیل Datalink تمرینات تحقیقات بالینی در مورد الگوهای درمان ضدافسردگی و هزینه های مراقبت های بهداشتی در اختلال اضطراب عمومی
کلمات کلیدی
ضد افسردگی؛ اختلال اضطراب عمومی؛ پایگاه اطلاعات تحقیقاتی عمومی؛ هزینه های مراقبت های بهداشتی؛ استفاده از منابع مراقبت بهداشتی
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی پزشکی و دندانپزشکی (عمومی)
چکیده انگلیسی

ObjectiveTo describe real-life prescription patterns, health care resource use, and costs in adults with generalized anxiety disorder (GAD) initiating antidepressant (AD) treatment in the United Kingdom.MethodsA retrospective longitudinal cohort study using data from Clinical Research Practice Datalink was conducted. Adults with incident prescription of an AD (index date) between January 1, 2006, and June 30, 2010, and with a diagnosis of GAD within the 2 months preceding or following the index date were included. Patients with a diagnosis of schizophrenia or bipolar disorder were excluded.ResultsA total of 29,131 patients with GAD were included in the analysis. Their mean age was 48.5 ± 15.5 years, and two thirds were women. GAD-licensed ADs (i.e., escitalopram, paroxetine, venlafaxine XR, and duloxetine) represented only 12.5% of the index AD prescriptions. At least one anxiolytic was prescribed for 23.5% of the patients. Only 33.2% of the patients continued index AD treatment over the study period. Discontinuation occurred for 46.0% of the patients, after a mean of 3.7 months of treatment. The health care costs were £338.4 per patient in the 6 months before the index date and £984.6 in the 9 months after the index date. Psychiatric hospitalization (relative risk = 4.18; 95% CI 3.53–4.96; P < 0.001) and duloxetine as index treatment (relative risk = 1.85; 95% CI 1.30–2.63; P < 0.001) were the main determinants of increased costs for these patients.ConclusionsThe significant rate of AD discontinuation and associated treatment duration indicate unmet needs among patients with GAD. As described in American studies, substantial health care costs were also observed in this study.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Value in Health - Volume 16, Issue 8, December 2013, Pages 1133–1139
نویسندگان
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