کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9910135 | 1548651 | 2005 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Genotoxic effects of eugenol, isoeugenol and safrole in the wing spot test of Drosophila melanogaster
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
تحقیقات سرطان
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Genotoxic effects of eugenol, isoeugenol and safrole in the wing spot test of Drosophila melanogaster Genotoxic effects of eugenol, isoeugenol and safrole in the wing spot test of Drosophila melanogaster](/preview/png/9910135.png)
چکیده انگلیسی
In the present study, the phenolic compounds eugenol, isoeugenol and safrole were investigated for genotoxicity in the wing spot test of Drosophila melanogaster. The Drosophila wing somatic mutation and recombination test (SMART) provides a rapid means to evaluate agents able to induce gene mutations and chromosome aberrations, as well as rearrangements related to mitotic recombination. We applied the SMART in its standard version with normal bioactivation and in its variant with increased cytochrome P450-dependent biotransformation capacity. Eugenol and safrole produced a positive recombinagenic response only in the improved assay, which was related to a high CYP450-dependent activation capacity. This suggests, as previously reported, the involvement of this family of enzymes in the activation of eugenol and safrole rather than in its detoxification. On the contrary, isoeugenol was clearly non-genotoxic at the same millimolar concentrations as used for eugenol in both the crosses. The responsiveness of SMART assays to recombinagenic compounds, as well as the reactive metabolites from eugenol and safrole were considered responsible for the genotoxicity observed.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Mutation Research/Genetic Toxicology and Environmental Mutagenesis - Volume 582, Issues 1â2, 4 April 2005, Pages 87-94
Journal: Mutation Research/Genetic Toxicology and Environmental Mutagenesis - Volume 582, Issues 1â2, 4 April 2005, Pages 87-94
نویسندگان
Maria Cristina Munerato, Marialva Sinigaglia, Maria LuÃza Reguly, HeloÃsa Helena Rodrigues de Andrade,