کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9912069 | 1549424 | 2005 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Expression of CD24 on CD19âCD79a+ early B-cell progenitors in human bone marrow
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
بیولوژی سلول
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
CD24 is a surface marker expressed in immature and mature B cells and involved in cellular adhesion and apoptosis. There are no data, which delineate the stage in early development of human B cells, which marks the expression of CD24. We studied lymphopoiesis in normal pediatric bone marrow (BM) and found that 1.5 ± 0.2% of WBC were CD24+ lymphocytes which did not express CD19. A significant fraction of these cells expressed low levels of CD45 (CD19âCD24+CD45low cells). Small numbers of CD19âCD24+CD45low cells were found in the regenerating BM of children with acute lymphoblastic leukemia after the completion of chemotherapy and in normal adult BM. Flow cytometric analyses have shown that CD19âCD24+CD45low lymphocytes express CD10, CD34, CD79a, CD179a (VpreB), and TdT markers, i.e., displayed antigenic properties of early B-cell progenitors. Our data indicate that CD19â early B-cell progenitors in human BM express CD24, and that the expression of CD24 in human B-cell development precedes the expression of CD19.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Cellular Immunology - Volume 236, Issues 1â2, JulyâAugust 2005, Pages 171-178
Journal: Cellular Immunology - Volume 236, Issues 1â2, JulyâAugust 2005, Pages 171-178
نویسندگان
Elena Israel, Joseph Kapelushnik, Tikva Yermiahu, Itai Levi, Isaak Yaniv, Ofer Shpilberg, George Shubinsky,