کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9912211 | 1549509 | 2005 | 14 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
The role of the growth hormone/insulin-like growth factor axis in tumor growth and progression: Lessons from animal models
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
بیولوژی سلول
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: The role of the growth hormone/insulin-like growth factor axis in tumor growth and progression: Lessons from animal models The role of the growth hormone/insulin-like growth factor axis in tumor growth and progression: Lessons from animal models](/preview/png/9912211.png)
چکیده انگلیسی
Over the past two decades it has become widely appreciated that a relationship exists between the insulin-like growth factors (IGFs) and cancer. Many cancers have been shown to overexpress the IGF-I receptor and produce the ligands (IGF-I or IGF-II) and some combinations of the six IGF-binding proteins. With the recent demonstration by epidemiological studies that an elevated serum IGF-I level is associated with an increased relative risk of developing a number of epithelial cancers, interest has been sparked in this area of research with the possibility of targeting the IGF-I receptor in cancer treatment protocols. This review highlights many of the most relevant studies in this exciting area of research, focusing in particular on lessons learned from animal models of cancer.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Cytokine & Growth Factor Reviews - Volume 16, Issues 4â5, AugustâOctober 2005, Pages 407-420
Journal: Cytokine & Growth Factor Reviews - Volume 16, Issues 4â5, AugustâOctober 2005, Pages 407-420
نویسندگان
Shoshana Yakar, Derek LeRoith, Pnina Brodt,