کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9914896 | 1551014 | 2005 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Effect of IPs, cAMP, and cGMP on the hPL and hCG secretion from human term placenta
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
بیولوژی سلول
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Effect of IPs, cAMP, and cGMP on the hPL and hCG secretion from human term placenta Effect of IPs, cAMP, and cGMP on the hPL and hCG secretion from human term placenta](/preview/png/9914896.png)
چکیده انگلیسی
The acute control of human placental lactogen (hPL) and chorionic gonadotrophin (hCG) secretion by the placenta remains elusive. The in vitro release of both hormones can be stimulated by calcium inflow and by albumin. To investigate the placental secretory response to putative ligand(s) present in the maternal circulation, we evaluated the coupling of the hPL and hCG releases from term placenta with intracellular signaling pathways. Addition of NaF, forskolin or sodium nitroprusside, activators of the inositol phosphates (IPs), cAMP and cGMP pathways, significantly increased their respective messengers in villous explants but failed to affect the hPL and hCG releases from syncytiotrophoblast. By contrast, albumin did not modify the IPs, cAMP and cGMP villous content but significantly stimulated the placental hormonal release. These data suggest that the hPL and hCG secretion is not regulated through the IPs, cAMP and cGMP signaling pathways.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Molecular and Cellular Endocrinology - Volume 243, Issues 1â2, 24 November 2005, Pages 80-85
Journal: Molecular and Cellular Endocrinology - Volume 243, Issues 1â2, 24 November 2005, Pages 80-85
نویسندگان
Lambot Nathalie, Lebrun Philippe, Delporte Christine, De Vriese Carine, Delogne-Desnoeck Josiane, Vanbellinghen Anne Marie, Graff Guy, Meuris Sylvain,