کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9914932 | 1551017 | 2005 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
α1-Adrenergic receptor in rat ovary: Presence and localization
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
بیولوژی سلول
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چکیده انگلیسی
Noradrenaline modulates ovarian steroidogenesis, stimulates ovulation, and probably promotes follicular development in the ovary. It has been suggested that these effects of noradrenaline are mediated by α- and/or β-adrenergic receptors (ARs) in the ovary. The purpose of the present study was to examine whether α1-AR is present in the rat ovary. In Western blotting, antibody against α1-ARs recognized a major protein in the ovary of adult (10-week-old) rats with a molecular weight of 80 kDa, which is similar to that of the α1B-AR subtype. Immunohistochemistry using this antibody showed that α1-AR was detected at various sites in the ovary, including large antral follicle, germinal epithelium at the circumference of large antral follicle, corpus luteum, and interstitial tissue. These results confirm that the ovary contains α1-AR (probably α1B-subtype), and suggest that this receptor mediates some of the activities of noradrenaline in the regulation of ovarian functions. Furthermore, we found that α1-AR is present in oocyte of large antral follicle, suggesting that noradrenaline acts on oocyte via this receptor.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Molecular and Cellular Endocrinology - Volume 240, Issues 1â2, 30 August 2005, Pages 58-63
Journal: Molecular and Cellular Endocrinology - Volume 240, Issues 1â2, 30 August 2005, Pages 58-63
نویسندگان
Masanori T. Itoh, Bunpei Ishizuka,