کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9915059 | 1551028 | 2005 | 12 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Expression of nuclear receptor coregulators in ovarian stromal and epithelial tumours
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
بیولوژی سلول
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Expression of nuclear receptor coregulators in ovarian stromal and epithelial tumours Expression of nuclear receptor coregulators in ovarian stromal and epithelial tumours](/preview/png/9915059.png)
چکیده انگلیسی
Granulosa cell tumours of the ovary (GCT) exhibit high expression of estrogen receptor β (ERβ). A role for estrogen receptors in these tumours may depend on altered co-activator expression. This study examines the expression of the co-activators SRC-1a/e, SRC-2, SRC-3, SRA, and the corepressors NCoR and SMRT in GCT, epithelial ovarian tumours and normal ovary. No significant difference in the expression of SRC-1, SRC-2, SRC-3 or NCoR and SMRT was found. In particular, there was no correlation of co-activator expression with ERβ expression. There was a significant upregulation in the expression of the novel RNA co-activator SRA in the serous tumours compared with the other tumour types and normal ovary. The findings suggest that ERβ may require co-activators, other than members of the SRC family for the modulation of transcription in GCT.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Molecular and Cellular Endocrinology - Volume 229, Issues 1â2, 14 January 2005, Pages 149-160
Journal: Molecular and Cellular Endocrinology - Volume 229, Issues 1â2, 14 January 2005, Pages 149-160
نویسندگان
S. Hussein-Fikret, P.J. Fuller,