کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9917720 | 1556310 | 2005 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Amphiphilic amino acid copolymers as stabilizers for the preparation of nanocrystal dispersion
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت
داروسازی، سم شناسی و علوم دارویی
اکتشاف دارویی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Amphiphilic amino acid copolymers as stabilizers for the preparation of nanocrystal dispersion Amphiphilic amino acid copolymers as stabilizers for the preparation of nanocrystal dispersion](/preview/png/9917720.png)
چکیده انگلیسی
The recent advance of particle size engineering in nanometer ranges has widened the formulation opportunities of relatively water-insoluble drugs. However, the 'nanoformulation' suffers from a lack of systematic understanding about the requirements of polymeric stabilizers. Furthermore, the polymers that can be used for the preparation of nanocrystals are so limited that finding a proper stabilizer for a given formulation is often difficult. In this study, amino acid copolymers whose properties can systematically be tailored are developed, and their morphological and compositional effects are investigated. Copolymers containing lysine (K) as their hydrophilic segments, and phenylalanine (F) or leucine (L) as their hydrophobic segments successfully produce stable nanocrystals (200-300Â nm) in water, while copolymers of K and alanine (A) could not generate nanosized particles. Not the morphology but the hydrophobicity of copolymers seems to be a critical parameter in the preparation of drug nanocrystals by wet comminution. The effective stabilization performance of copolymers requires the hydrophobic moiety content to be higher than 15Â mol%. Comminution for only 5Â min is long enough for nanocrystal preparation, and the crystallinity of drug is found intact after the processing.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Pharmaceutical Sciences - Volume 24, Issue 5, April 2005, Pages 441-449
Journal: European Journal of Pharmaceutical Sciences - Volume 24, Issue 5, April 2005, Pages 441-449
نویسندگان
Jonghwi Lee, Soo-Jeong Lee, Ji-Yeun Choi, Ji Youn Yoo, Cheol-Hee Ahn,