کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9920909 | 1559194 | 2005 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Effect of zotepine on dopamine, serotonin and noradrenaline release in rat prefrontal cortex
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب سلولی و مولکولی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Effect of zotepine on dopamine, serotonin and noradrenaline release in rat prefrontal cortex Effect of zotepine on dopamine, serotonin and noradrenaline release in rat prefrontal cortex](/preview/png/9920909.png)
چکیده انگلیسی
The present study examined the effect of zotepine, an atypical antipsychotic, on the in vivo release of monoamines in the prefrontal cortex of rats using microdialysis. Local perfusion of zotepine at 10 μM increased extracellular levels of serotonin (5-HT), as well as dopamine and noradrenaline, in the prefrontal cortex. However, systemic administration of zotepine did not affect 5-HT release, although it increased the dopamine and noradrenaline release. These results suggest that the prefrontal 5-HT system does not contribute to the antidepressant effect of zotepine. The difference in the effect of zotepine between local and systemic treatment is discussed.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Pharmacology - Volume 528, Issues 1â3, 28 December 2005, Pages 95-98
Journal: European Journal of Pharmacology - Volume 528, Issues 1â3, 28 December 2005, Pages 95-98
نویسندگان
Shigeo Nakamura, Yukio Ago, Soichi Itoh, Yutaka Koyama, Akemichi Baba, Toshio Matsuda,