(2E,6Z,10E)-7-hydroxymethyl-3,11,15-trimethyl-2,6,10,14-hexadecatetraen-1-ol (Plaunotol) increases cyclooxygenase-2 expression via nuclear factor κB and cyclic AMP response element in rat gastric epithelial cells

In conclusion, plaunotol induced COX-2 expression and increased PGE2 production in serum-starved RGM1 cells via activation of the NF-κB and CRE sites of Cox-2 gene promoters.