کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9921023 | 1559198 | 2005 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Enhanced response of pig coronary arteries to endothelin-1 after ischemia-reperfusion. Role of endothelin receptors, nitric oxide and prostanoids
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب سلولی و مولکولی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
To analyse the coronary effects of endothelin-1 after ischemia-reperfusion, the left anterior descending coronary artery of anesthetized pigs was subjected to 30-min occlusion followed by 60-min reperfusion. Then, rings distal (ischemic arteries) and proximal (control arteries) to the occlusion were taken from this artery and prepared for isometric tension recording. The sensitivity of the contraction in response to endothelin-1 (3 Ã 10â 10-3 Ã 10â 7 M) and the endothelin ETB receptor agonist IRL-1620 (3 Ã 10â 10-3 Ã 10â 7 M) was greater in ischemic vessels. The endothelin ETA receptor antagonist BQ-123 (10â 7-3 Ã 10â 6 M) decreased the sensitivity of the response to endothelin-1 similarly in ischemic and control arteries. The endothelin ETB receptor antagonist BQ-788 (10â 6 M), endothelium removal or the inhibitor of nitric oxide synthesis NÏ-nitro-L-arginine methyl ester (L-NAME 10â 4 M) potentiated the response to endothelin-1 and IRL-1620 in control arteries only. The cyclooxygenase inhibitor meclofenamate (10â 5 M) augmented the maximal response to endothelin-1 in control arteries, and reduced it in ischemic arteries. In precontracted arteries, IRL-1620 (3 Ã 10â 11-3 Ã 10â 10 M) relaxed control but not ischemic arteries, and L-NAME or meclofenamate abolished this relaxation. Therefore, ischemia-reperfusion increases the coronary vasoconstriction in response to endothelin-1 probably due to impairment of endothelin ETB receptor-induced release of nitric oxide and prostacyclin, augmentation of the contractile response to activation of endothelin ETB receptors, and increased release of vasoconstrictor prostanoids.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Pharmacology - Volume 524, Issues 1â3, 7 November 2005, Pages 102-110
Journal: European Journal of Pharmacology - Volume 524, Issues 1â3, 7 November 2005, Pages 102-110
نویسندگان
Belén Climent, Nuria Fernández, Elena Sanz, Ana Sánchez, Luis Monge, Angel Luis GarcÃa-Villalón, Godofredo Diéguez,