کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9921045 | 1559199 | 2005 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Differential G-protein coupling to GABAB receptor in limbic areas of alcohol-preferring and -nonpreferring rats
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب سلولی و مولکولی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Differential G-protein coupling to GABAB receptor in limbic areas of alcohol-preferring and -nonpreferring rats Differential G-protein coupling to GABAB receptor in limbic areas of alcohol-preferring and -nonpreferring rats](/preview/png/9921045.png)
چکیده انگلیسی
The function of the γ-aminobutyric acidB (GABAB) receptor, measured as baclofen-stimulated [35S]GTPγS binding, was evaluated in some brain regions of Sardinian alcohol-preferring (sP) and -nonpreferring (sNP) rats. EC50 value of baclofen-stimulated [35S]GTPγS in limbic areas was approximately 125% higher in alcohol-naive sP than sNP rats; voluntarily consumed alcohol reduced the EC50 value to a level similar to that of alcohol-naive sNP rats. These results suggest the presence of a genetically determined lower function of the GABAB receptor in limbic areas of sP than sNP rats; this differential functioning of the GABAB receptor may contribute to the opposite preference for alcohol in these rat lines.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Pharmacology - Volume 523, Issues 1â3, 31 October 2005, Pages 67-70
Journal: European Journal of Pharmacology - Volume 523, Issues 1â3, 31 October 2005, Pages 67-70
نویسندگان
M. Paola Castelli, Fabio Pibiri, A. Paola Piras, Giovanni Carboni, Alessandro Orrù, Gian Luigi Gessa, Mauro A.M. Carai, Giancarlo Colombo,