کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
9921045 1559199 2005 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Differential G-protein coupling to GABAB receptor in limbic areas of alcohol-preferring and -nonpreferring rats
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب سلولی و مولکولی
پیش نمایش صفحه اول مقاله
Differential G-protein coupling to GABAB receptor in limbic areas of alcohol-preferring and -nonpreferring rats
چکیده انگلیسی
The function of the γ-aminobutyric acidB (GABAB) receptor, measured as baclofen-stimulated [35S]GTPγS binding, was evaluated in some brain regions of Sardinian alcohol-preferring (sP) and -nonpreferring (sNP) rats. EC50 value of baclofen-stimulated [35S]GTPγS in limbic areas was approximately 125% higher in alcohol-naive sP than sNP rats; voluntarily consumed alcohol reduced the EC50 value to a level similar to that of alcohol-naive sNP rats. These results suggest the presence of a genetically determined lower function of the GABAB receptor in limbic areas of sP than sNP rats; this differential functioning of the GABAB receptor may contribute to the opposite preference for alcohol in these rat lines.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Pharmacology - Volume 523, Issues 1–3, 31 October 2005, Pages 67-70
نویسندگان
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