کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9921074 | 1559200 | 2005 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Post-exposure administration of edaravone attenuates noise-induced hearing loss
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب سلولی و مولکولی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
We investigated the effects of the antioxidant edaravone against acoustic trauma in guinea pigs. Edaravone (1.722 Ã 10â 2 M) was infused into the right ear by an osmotic pump, and the left ear was untreated for control. Animals received edaravone 9 h before (â 9 h group, n = 7) and 9 h (+ 9 h group, n = 8), 21 h (+ 21 h group, n = 7) and 33 h (+ 33 h group, n = 4) after 3-h exposure to 130-dB noise. Seven days after noise exposure, we examined the shift in auditory brainstem response thresholds and histopathologic characteristics of the sensory epithelia. The smallest shift in auditory brainstem response threshold and smallest proportion of missing outer hair cells were observed in the + 9 h group. This result was supported by immunohistochemical analysis of 4-hydroxy-2-nonenal. Our data suggest that edaravone may be clinically effective in the treatment of acoustic trauma, especially if given within 21 h of noise exposure.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Pharmacology - Volume 522, Issues 1â3, 17 October 2005, Pages 116-121
Journal: European Journal of Pharmacology - Volume 522, Issues 1â3, 17 October 2005, Pages 116-121
نویسندگان
Kuniyoshi Tanaka, Tsuyoshi Takemoto, Kazuma Sugahara, Takeshi Okuda, Takefumi Mikuriya, Kenji Takeno, Makoto Hashimoto, Hiroaki Shimogori, Hiroshi Yamashita,