کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9921076 | 1559200 | 2005 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Inhibitory effects of histamine H4 receptor antagonists on experimental colitis in the rat
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب سلولی و مولکولی
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چکیده انگلیسی
The histamine H4 receptor is a G-protein coupled receptor with little homology to the pro-inflammatory histamine H1 receptor, expressed on cells of the immune system with hematopoietic lineage such as eosinophils and mast cells. The effects of the recently described highly selective histamine H4 receptor antagonists JNJ 10191584 and JNJ 7777120 have now been investigated on the acute colitis provoked by trinitrobenzene sulphonic acid over 3 days in the rat. Treatment with JNJ 10191584 (10-100 mg/kg p.o., b.i.d.) caused a dose-dependent reduction in macroscopic damage, inhibition of the TNBS-provoked elevation of both colonic myeloperoxidase and tumour necrosis factor-α (TNF-α), and a reduction in the histologically assessed increase in mucosal and submucosal thickness and neutrophil infiltration. JNJ 7777120 (100 mg/kg p.o., b.i.d.) likewise reduced the macroscopic injury and the increases in colonic myeloperoxidase and TNF-α levels. These findings indicate a pro-inflammatory role for the histamine H4 receptor in this model and suggest a novel pharmacological approach to the treatment of colitis.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Pharmacology - Volume 522, Issues 1â3, 17 October 2005, Pages 130-138
Journal: European Journal of Pharmacology - Volume 522, Issues 1â3, 17 October 2005, Pages 130-138
نویسندگان
Csaba Varga, Krisztina Horvath, Aniko Berko, Robin L. Thurmond, Paul J. Dunford, Brendan J.R. Whittle,