The role of 5-HT2A receptor antagonism in amphetamine-induced inhibition of A10 dopamine neurons in vitro

We conclude that 5-HT2A receptor antagonism enhanced reversal of amphetamine-induced inhibition by dopamine D2 antagonism in A10, suggesting that dopamine D2 receptor antagonism combined with 5-HT2A receptor antagonism may play a role in antipsychotic drug atypicality.