کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9921260 | 1559209 | 2005 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Differential action of domperidone to modify emesis and behaviour induced by apomorphine in the ferret
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب سلولی و مولکولی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Differential action of domperidone to modify emesis and behaviour induced by apomorphine in the ferret Differential action of domperidone to modify emesis and behaviour induced by apomorphine in the ferret](/preview/png/9921260.png)
چکیده انگلیسی
The action of domperidone (1 mg/kg, i.p.) on spontaneous behaviour and the emesis and behavioural change induced by apomorphine (0.25 mg/kg, s.c.) were studied in the ferret. Domperidone was inactive to modify spontaneous behaviour but apomorphine-induced emesis and increased locomotor activity (distance travelled and velocity of movement; PÂ <Â 0.05); the emesis, but not the modification of locomotor activity was antagonized significantly (PÂ <Â 0.01) by domperidone. However, apomorphine did not modify significantly other behavioural measures (i.e. lip licking, rearing, burrowing, backward walking, curling-up activity, or defecatory frequency; PÂ >Â 0.05). The action of apomorphine to modify behaviour and its interaction with domperidone in this species is discussed in relation to animal models of nausea.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Pharmacology - Volume 516, Issue 3, 15 June 2005, Pages 247-252
Journal: European Journal of Pharmacology - Volume 516, Issue 3, 15 June 2005, Pages 247-252
نویسندگان
Angie H.Y. Lau, Man-P. Ngan, John A. Rudd, David T.W. Yew,