کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
9921327 1559213 2005 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Effects of the high-efficacy 5-HT1A receptor agonist, F 13640 in the formalin pain model: A c-Fos study
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب سلولی و مولکولی
پیش نمایش صفحه اول مقاله
Effects of the high-efficacy 5-HT1A receptor agonist, F 13640 in the formalin pain model: A c-Fos study
چکیده انگلیسی
We studied the effects of the high-efficacy 5-hydroxytryptamine1A (5-HT1A) receptor agonist, F 13640 on both formalin-induced spinal cord c-Fos protein expression and pain behaviours in the rat. Replicating earlier data, F 13640 (0.63 mg/kg, i.p.; t−15 min) completely inhibited the elevation and licking of the formalin-injected paw. In the same animals, and in spite of the agent as in earlier data increasing the number of c-Fos labelled nuclei when it was administered alone, F 13640 markedly reduced the number of formalin-induced c-Fos labelled nuclei. This was found in both the superficial (I-II) and deep (V-VI) dorsal horn laminae (2 h post-injection: 72 ± 2% and 92 ± 1% of reduction, respectively; P < 0.001 in either case), spinal areas that contain neurons responsive to nociceptive stimulation. Co-operation occurred so that after the co-administration of F 13640 and formalin, c-Fos expression was inferior to that induced when either stimulation was administered alone. The data provide initial evidence for the agent's inhibitory effects on noxiously evoked c-Fos expression. The results indicate that co-operation between 5-HT1A receptor activation and nociceptive stimulation powerfully inhibits responses to severe, tonic nociception.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Pharmacology - Volume 514, Issues 2–3, 9 May 2005, Pages 121-130
نویسندگان
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