کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9921354 | 1559215 | 2005 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Hydrogen peroxide and endothelium-dependent hyperpolarization in the guinea-pig carotid artery
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب سلولی و مولکولی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Hydrogen peroxide and endothelium-dependent hyperpolarization in the guinea-pig carotid artery Hydrogen peroxide and endothelium-dependent hyperpolarization in the guinea-pig carotid artery](/preview/png/9921354.png)
چکیده انگلیسی
This study was designed to determine whether or not endothelium-dependent hyperpolarizations evoked by acetylcholine in the isolated guinea-pig carotid artery involve hydrogen peroxide. Membrane potential was recorded in the vascular smooth muscle cells of that artery. Under control conditions, acetylcholine induced endothelium-dependent hyperpolarization of the vascular smooth muscle cells which was not affected by the presence of catalase, superoxide dismutase or their combination. Neither the superoxide dismutase mimetic, tiron nor the thiol-reducing agent N-acetyl-l-cysteine modified the hyperpolarization evoked by 0.1 μM acetylcholine but each produced a partial and significant inhibition of the hyperpolarization induced by 1 μM acetylcholine. Neither 10 nor 100 μM hydrogen peroxide influenced the resting membrane potential of the smooth muscle cells and the higher concentration did not significantly influence the hyperpolarization elicited by acetylcholine. These data indicate that, in the guinea-pig isolated carotid artery, hydrogen peroxide is unlikely to contribute to the endothelium-dependent hyperpolarization evoked by acetylcholine.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Pharmacology - Volume 513, Issue 3, 25 April 2005, Pages 219-224
Journal: European Journal of Pharmacology - Volume 513, Issue 3, 25 April 2005, Pages 219-224
نویسندگان
Pascale Gluais, Gillian Edwards, Arthur H. Weston, Paul M. Vanhoutte, Michel Félétou,