کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
9921375 1559216 2005 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The role of substance P and bradykinin in the cough reflex and bronchoconstriction in guinea-pigs
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب سلولی و مولکولی
پیش نمایش صفحه اول مقاله
The role of substance P and bradykinin in the cough reflex and bronchoconstriction in guinea-pigs
چکیده انگلیسی
In this study we investigated the ability of aerosolized substance P to induce either cough or bronchoconstriction in guinea-pigs. We have also examined whether pre-treatment, by the inhaled route, of animals with a combination of the neutral endopeptidase inhibitor, phosphoramidon (10−3 M), and the diaminopeptidase IV inhibitor, diprotin A (10−3 M), enhances the airway response to substance P. Moreover, we also assessed whether aerosol pre-treatment of guinea-pigs with either substance P or bradykinin, at 10−4 M, affects the citric acid-induced cough and/or bronchoconstriction. Challenge of guinea-pigs with substance P only at 10−3 M resulted in significant bronchconstriction but only a weak and variable cough response (1.1±0.6; P>0.05). Pre-treatment of guinea-pigs with both phosphoramidon and diprotin A resulted in a small non-significant increase in the cough response (2.8±0.9 vs. 1.1±0.6; P>0.05) but significantly enhanced substance P-induced bronchoconstriction (P<0.05). Moreover, exposure of guinea-pigs to substance P (10−4 M) prior to citric acid challenge (0.6M) resulted in a significant (P<0.05) enhancement of the citric acid-induced bronchoconstriction but not the citric acid-induced cough (11.7±1.8 vs. 12.8±1.5; P>0.05). In contrast, exposure of guinea-pigs to bradykinin (10−4 M) prior to the citric acid challenge resulted in a significant enhancement of the cough response (9.2±1.9 vs. 25.8±2.5; P<0.05) but not the bronchoconstriction (P>0.05). These data do not support a major peripheral role for substance P in the cough reflex, although bradykinin is able to sensitize the cough reflex. Furthermore, these data suggest that bronchoconstriction, induced by citric acid, is not responsible for the cough associated with this irritant.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Pharmacology - Volume 513, Issues 1–2, 18 April 2005, Pages 125-133
نویسندگان
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