کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9921376 | 1559216 | 2005 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Evidence for the presence of P2y and P2x receptors with different functions in mouse stomach
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب سلولی و مولکولی
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چکیده انگلیسی
To clarify the function of P2 receptor subtypes in mouse stomach, the motor responses to ATP, α,β-methyleneATP (α,β-MeATP), P2X receptor agonist, 2-methylthioATP (2-MeSATP), P2Y receptor agonist, and the effects of the desensitisation of P2X receptors with α,β-MeATP and of P2Y receptors with ADPβS were analysed recording the endoluminal pressure from whole-organ. ATP-induced relaxation was antagonised by suramin, non-selective P2 receptor antagonist, by desensitisation of P2Y receptors with ADPβS, and increased by desensitisation of P2X receptors with α,β-MeATP. α,β-MeATP produced biphasic responses: relaxation, reduced by P2X- or P2Y desensitisation, and contraction, almost abolished by P2X desensitisation and potentiated by P2Y desensitisation. 2-MeSATP induced relaxation, which was antagonised by P2Y desensitisation and increased by P2X desensitisation. Tetrodotoxin increased the relaxation induced by purines and deeply antagonised the contraction to α,β-MeATP. Our results suggest that in mouse stomach are present muscular P2Y receptors, subserving relaxation, and neuronal presynaptic P2X receptors, mediating contraction.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Pharmacology - Volume 513, Issues 1â2, 18 April 2005, Pages 135-140
Journal: European Journal of Pharmacology - Volume 513, Issues 1â2, 18 April 2005, Pages 135-140
نویسندگان
Flavia Mulè, Davide Naccari, Rosa Serio,