کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
9921389 1559218 2005 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Heterogenic contractile response of rat left ventricular myocytes to β1-adrenoceptor stimulation
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب سلولی و مولکولی
پیش نمایش صفحه اول مقاله
Heterogenic contractile response of rat left ventricular myocytes to β1-adrenoceptor stimulation
چکیده انگلیسی
We measured the contractile response of left ventricular cardiac myocytes from female rats to selective β1-adrenoceptor stimulation (isoprenaline, 10−8 M and 10−7 M in the presence of 10−7 M ICI 118,551 a β2-adrenoceptor inverse agonist). A heterogenic response to stimulation, inversely related to the extent of cell shortening prior to adrenergic stimulation, was observed. Challenge of cardiac myocytes with a selective β1-antagonist, atenolol (10−7 M), suggests the heterogenic response is not caused by basal β1-adrenoceptor activity. Thus, basal myocyte contractility determines the response to β1-adrenoceptor stimulation, this should be taken into account when experimental conditions are designed.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Pharmacology - Volume 512, Issues 2–3, 11 April 2005, Pages 117-120
نویسندگان
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